Vardenafil hydrochloride Trihydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction.

Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.

Vardenafil; Levitra; Staxyn; Vivanza; BAY 38-9456

Angiogenesis

PDE

PDE1; PED5

Endocrinology

——

224785-90-4

579.11

C23H32N6O4S·HCl·3H2O

>98%(HPLC)

Ethanol: 20 mg/mL (34.53 mM); Water: 116 mg/mL (200.3 mM); DMSO: 116 mg/mL (200.3 mM)

O=C(NC(C1=CC(S(=O)(N2CCN(CC)CC2)=O)=CC=C1OCC)=N3)[N]4(C)C3=CN(CCC)C4

2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propyl-3,5,6,7-tetrahydro-4H-5l4-imidazo[1,5-a][1,3,5]triazin-4-one

(-20℃)

With Ice Pack

≥ 2 years